Cognitive Aging in Older Long-term Breast Cancer Survivors

Status: Recruiting
Location: See all (7) locations...
Intervention Type: Other
Study Type: Observational
SUMMARY

The purpose of this study is to look at how differences in cognitive (mental) function develop over time in breast cancer survivors compared to volunteers without a history of cancer (healthy volunteers). Both cancer survivors and healthy volunteers (who are the same age as the cancer survivors) will participate in this study so the researchers can compare the results of neurocognitive testing (which looks at memory, attention, and information processing) on each group of participants.

Eligibility
Participation Requirements
Sex: Female
Minimum Age: 60
Maximum Age: 80
Healthy Volunteers: t
View:

• All Participants:

• Per medical record and/or self-report, identifies as female

• Per medical record and/or self-report, currently age 60-80

• Per self-report, has access to a computer and internet connectivity

• Score of \<11 on Blessed Orientation-Memory-Concentration Test (BOMC)

• As per medical record or self-report, if currently taking psychoactive medications (including but not limited to antidepressants and anxiolytics), dose must have been stable at least two months prior to enrollment.

• English fluent (as per self-report, fluency of well or very well, and having a reasonable comprehension of the study conversation in the opinion of the research staff)\*\*

• Breast Cancer Survivors:

• Per medical record and/or self-report, history of stage 0-3 breast cancer diagnosed between 50-60 years of age

• Per medical record and/or self-report, no evidence of disease (NED)

• Non-Cancer Controls:

• Per self-report, no history of breast cancer

⁃ Language verification: For both survivors and controls, prior to enrollment, all will be asked the following two questions by a CRC to verify English fluency necessary for participation in the study:

∙ How well do you speak English? (must respond Well or Very well when given the choices of Very well, Well, Not well, Not at all, Don't know, or Refused)

‣ What is your preferred language for healthcare? (must respond English)

Locations
United States
New Jersey
Memorial Sloan Kettering Basking Ridge (All Protocol Activities)
RECRUITING
Basking Ridge
Memorial Sloan Kettering Monmouth (All protocol activities)
RECRUITING
Middletown
Memorial Sloan Kettering Bergen (All Protocol Activities)
RECRUITING
Montvale
New York
Memorial Sloan Kettering Suffolk - Commack (All Protocol Activities)
RECRUITING
Commack
Memorial Sloan Kettering Westchester (All Protocol Activities)
RECRUITING
Harrison
Memorial Sloan Kettering Cancer Center
RECRUITING
New York
Memorial Sloan Kettering Nassau (All Protocol Activities)
RECRUITING
Uniondale
Contact Information
Primary
James Root, PhD
rootj@mskcc.org
646-888-0035
Backup
Tim Ahles, PhD
646-888-0048
Time Frame
Start Date: 2024-05-10
Estimated Completion Date: 2028-08-31
Participants
Target number of participants: 420
Treatments
Breast Cancer Survivor (BCS)
Enrolled participants will be asked to complete a one-time, remote neurocognitive assessment. The neurocognitive assessment will consist of the CogSuite Neurocognitive Battery, an online, remotely deliverable battery of cognitive experimental measures, and a standard battery of remote neuropsychological measures. DNA will be collected via mailed saliva kits to assess Apolipoprotein E (APOE) status.
Non-cancer Control (NCC)
Enrolled participants will be asked to complete a one-time, remote neurocognitive assessment. The neurocognitive assessment will consist of the CogSuite Neurocognitive Battery, an online, remotely deliverable battery of cognitive experimental measures, and a standard battery of remote neuropsychological measures. DNA will be collected via mailed saliva kits to assess Apolipoprotein E (APOE) status.
Related Therapeutic Areas
Sponsors
Leads: Memorial Sloan Kettering Cancer Center

This content was sourced from clinicaltrials.gov